多奈哌齐联合盐酸美金刚、尼莫地平治疗老年痴呆的效果及对记忆功能、脑微循环的影响

Effect of donepezil combined with memantine hydrochloride and nimodipine in treatment of elderly dementia and its impact on memory function and cerebral microcirculation

摘要:

目的 将多奈哌齐与盐酸美金刚、尼莫地平联用，分析其治疗老年痴呆的效果。方法 选取2021年1月至2022年7月洛阳市东方人民医院收治的62例老年痴呆患者进行研究，随机分为两组，对照组31例（盐酸美金刚、多奈哌齐），观察组31例（多奈哌齐联合盐酸美金刚、尼莫地平），比较两组的治疗效果、记忆功能评分及脑部微循环指标。结果 观察组治疗效果优于对照组（P<0.05）；治疗后，观察组记忆功能各维度评分均高于对照组（P<0.05）；治疗后，观察组右侧椎动脉、左侧椎动脉、基底动脉血流量均高于对照组（P<0.05）。结论 多奈哌齐联合盐酸美金刚、尼莫地平治疗老年痴呆效果满意，可改善患者记忆功能与脑微循环状态，值得推广应用。

Abstract:

Objective To analyze the efficacy of donepezil in combination with memantine hydrochloride and nimodipine in elderly dementia.Methods During the period from January 2021 to July 2022, 62 elderly dementia patients treated in Luoyang Dongfang People's Hospital were selected and randomly divided into two groups. The control group consisted of 31 patients (memantine hydrochloride and donepezil), and the treatment group consisted of 31 patients (donepezil combined with memantine hydrochloride and nimodipine). The treatment effects, memory function score and brain microcirculation indicators were compared.Results The total effective rate of treatment in the treatment group was significantly higher than that in the control group (P<0.05); after therapy, the scores of memory function in all dimensions in the treatment group were higher than those in the control group (P<0.05); after therapy, the blood flow of the right vertebral artery, left vertebral artery, and basilar artery in the treatment group was higher than that in the control group (P<0.05).Conclusion The combination of donepezil, memantine hydrochloride, and nimodipine has a satisfactory therapeutic effect on elderly dementia, which can improve patients' memory function and cerebral microcirculation, and is worthy of promotion and application.