分析磷酸奥司他韦影响成人流行性感冒预后的影响因素

Influencing factors of oseltamivir phosphate on the prognosis of adult influenza

摘要:

目的 分析成人流行性感冒（简称流感）应用磷酸奥司他韦治疗的效果观察，并分析其影响预后的因素。方法 选取郑州市第七人民医院感染性疾病科2021年1月至2023年2月收治的100例流行性感冒的患者，将其给予所有患者服用奥司他韦胶囊进行治疗，并根据患者临床检验指标等信息，分析其效果与影响因素。结果 100例流行性感冒的患者，经治疗后发现，治愈30例，有效10例，无效10例，临床总有效率为80.00%；将单因素分析P<0.05差异有统计学意义的指标，包括发热、超敏C反应蛋白、重症肺炎、白介素-6、丙氨酸氨基转移酶、天冬氨酸转氨酶以及白蛋白的初始指标值纳入Logistic回归多因素分析中，将临床疗效作为自变量，经结果显示重症肺炎和超敏C反应蛋白为影响服用奥司他韦临床疗效的危险因素（P<0.05）。结论 重症肺炎和超敏C反应蛋白为影响服用奥司他韦治疗流行性感冒临床疗效的预后影响因素，故临床治疗使用磷酸奥司他韦时应严格把控。

关键词:流行性感冒;奥司他韦胶囊;发热;临床疗效

Abstract:

Objective To explore the influencing factors of oseltamivir phosphate on the prognosis of adult influenza, and to provide reference for clinical therapeutic use.Methods A total of 100 cases of influenza patients admitted to the Infectious Diseases Department of Zhengzhou Seventh People's Hospital from January 2021 to February 2023 were given oseltamivir phosphate capsule by oral administration to observe the therapeutic effect and prognostic factors of the patients.Results After treatment, 30 cases were cured, 10 cases were effective and 10 cases were ineffective. The total clinical effective rate was 80.00%. Statistically significant indicators with single factor P<0.05, such as fever, hypersensitive C-reactive protein, severe pneumonia, interleukin-6, aspartic acid transferase, alanine aminotransferase and albumin, were included in Logistic regression analysis, and clinical efficacy was taken as dependent variable (good prognosis=1, poor prognosis=0). The results of clinical analysis showed that severe pneumonia and hypersensitive C-reactive protein were the risk factors affecting the efficacy of oseltamivir (P<0.05).Conclusion Severe pneumonia and hypersensitive C-reactive protein are prognostic factors affecting the clinical efficacy of oseltamivir in the treatment of influenza, so the use of oseltamivir phosphate in clinical treatment should be strictly controlled.

Key words:influenza;oseltamivir capsule;heat;clinical effect