血液透析并血液灌流治疗糖尿病肾病的疗效及对脂肪因子与炎症因子的影响

Effect of hemodialysis and hemoperfusion on diabetic nephropathy and its influence on adipokines and inflammatory factors

摘要:

目的 分析糖尿病肾病（DN）患者采用血液透析并血液灌流治疗的疗效及对脂肪因子与炎症因子的影响。方法 将2019年7月至2022年11月济源市人民医院收治的80例DN患者随机分为试验组和对照组，每组40例，分别给予血液透析并血液灌流治疗及血液透析联合血液透析滤过治疗。结果 试验组总有效率（67.50%）明显高于对照组（42.50%），两组临床疗效差异有统计学意义（P<0.05），试验组治疗后脂肪因子抵抗素、脂联素、瘦素改善较对照组明显，炎症因子［肿瘤坏死因子-α（TNF-α）、超敏C反应蛋白（hs-CRP）、白细胞介素-6（IL-6）］较对照组下降明显，两组治疗后脂肪因子与炎症因子差异有统计学意义（P<0.05）。结论 血液透析并血液灌流治疗可提高DN患者的临床疗效，有效改善脂肪因子与炎症因子。

关键词:糖尿病肾病;血液透析;血液灌流;临床疗效;脂肪因子;炎症因子

Abstract:

Objective To analyze the effect of hemodialysis and hemoperfusion on adipokines and inflammatory factors in patients with diabetes nephropathy (DN).Methods Eighty patients with DN admitted to Jiyuan People's Hospital were randomly divided into an experimental group and a control group, with 40 cases in each group. They were treated with hemodialysis and hemoperfusion therapy, as well as hemodialysis combined with hemodialysis filtration therapy.Results The total effective rate of 67.50% in the experimental group was significantly higher than that of 42.50% in the control group, and there was a significant difference in clinical efficacy between the two groups (P<0.05). After treatment, the experimental group showed significant improvement in the levels of fat factor resistin, adiponectin, and leptin compared with the control group. Inflammatory factors such as tumor necrosis factor-α (TNF-α), high-sensitivity C-reactive protein (hs-CRP), and interleukin-6 (IL-6) decreased significantly compared with the control group. After treatment, there was a significant difference in adipose factors and inflammatory factors between the two groups (P<0.05).Conclusion Hemodialysis combined with hemoperfusion therapy can improve the clinical efficacy of DN patients and effectively improve adipocytokines and inflammatory factors.

Key words:diabetes nephropathy;hemodialysis;blood perfusion;clinical efficacy;fatty factors;inflammatory factors