血液灌流联合血液透析对慢性肾衰竭患者炎性反应及钙磷代谢的影响

Effects of hemoperfusion combined with hemodialysis on inflammatory response and calcium and phosphorus metabolism in patients with chronic renal failure

摘要:

目的 分析应用联合治疗方案的效果。方法 收集安阳市第三人民医院2021年1月至2023年5月收治的80例慢性肾衰竭患者为受试者，根据系统随机化法将其进行分组处理，比例为1∶1。对照组（n=40）和观察组（n=40）分别给予血液透析治疗和血液透析联合血液灌流治疗。比较两组患者临床疗效、炎性反应、肾功能指标、钙磷代谢以及不良反应发生率。结果 组间治疗总有效率比较，观察组稍高于对照组（97.50%>82.50%），差异无统计学意义（P>0.05）。治疗后，观察组与对照组比较，白介素-6（IL-6）、肿瘤坏死因子（TNF-α）、C反应蛋白（CRP）均更低（P<0.05）；治疗后，观察组血肌酐（SCr）、尿素（BUN）指标均更低（P<0.05）；治疗后，观察组甲状旁腺激素（PTH）和血磷均更低，且血钙更高（P<0.05）；经对比试验，观察组不良反应发生率低于对照组（P<0.05）。结论 联合治疗方案安全系数高，治疗效果良好。

Abstract:

Objective To analyze the effect of combination therapy.Methods The study period was from January 2021 to May 2023. Eighty patients with chronic renal failure admitted to the Third People's Hospital of Anyang City were collected as subjects and divided into groups according to systematic randomization, with a ratio of 1:1. Control group (n=40) and observation group (n=40) were treated with hemodialysis and hemodialysis combined with hemoperfusion, respectively. The clinical efficacy, inflammatory response, renal function indexes, calcium and phosphorus metabolism and the incidence of adverse reactions were compared between the two groups.Results The total effective rate was compared between groups, and the observation group was slightly higher than the control group (97.50%>82.50%) (P>0.05). After treatment, interleukin-6 (IL-6), tumor necrosis factor (TNF-α) and C-reactive protein (CRP) were all lower in observation group (P<0.05). After treatment, serum creatinine (SCr) and urea (BUN) indexes were lower in observation group (P<0.05). After treatment, parathyroid hormone (PTH) and blood phosphorus were lower, and blood calcium was higher in observation group (P<0.05). The incidence of adverse reactions was lower in the observation group (P<0.05).Conclusion Combination therapy has high safety factor and good therapeutic effect.