乳牙患龋儿童口腔内微生物菌群与过渡性修复疗效的相关性研究

Relationship between oral microbiota and transitional repair effect in children with deciduous teeth caries

摘要:

目的 探讨乳牙患龋儿童口腔内微生物菌群与过渡性修复疗效的相关性。方法 选取2021年3月至2023年1月于驻马店市中心医院就诊的108例乳牙患龋儿童为研究对象，将研究对象按照乳牙患龋的程度分为轻度患龋组（58例）和重度患龋组（50例），以探讨不同程度患龋对口腔内微生物菌群与过渡性修复疗效相关性的影响。收集患者基本信息包括性别、年龄、有无正畸治疗史、刷牙是否有出血、牙齿是否松动、咀嚼是否无力、牙周治疗史、牙周炎家族史；测定口腔菌种，分析乳牙患龋儿童口腔内微生物菌群与过渡性修复疗效的相关性。结果 轻度患龋组唾液链球菌、鼠李糖乳杆菌、植物乳杆菌、罗伊氏乳杆菌、瑞士乳杆菌、短乳杆菌、乳酸乳杆菌、双歧杆菌、副干酪乳杆菌等有益菌含有人数比率高于重度患龋组（P<0.05）。轻度患龋组链变形链球菌、远缘链球菌、内氏放线菌、嗜酸乳杆菌等有害菌含有人数比率低于重度患龋组（P<0.05）。修复后有害菌含有人数比率低于修复前，有益菌含有人数比率高于修复前（P<0.05）。变形链球菌、远缘链球菌、内氏放线菌、嗜酸乳杆菌、唾液链球菌、鼠李糖乳杆菌、植物乳杆菌、罗伊氏乳杆菌、瑞士乳杆菌、短乳杆菌、乳酸乳杆菌、双歧杆菌、副干酪乳杆菌等菌种是影响乳牙患龋儿童口腔健康的因素（P<0.05）。结论 乳牙患龋儿童口腔内微生物菌群与过渡性修复疗效存在一定的相关性，这为优化乳牙患龋的治疗方案提供了科学依据。未来的研究可以进一步探讨不同治疗方式对乳牙患龋儿童口腔内微生物菌群与过渡性修复疗效相关性的影响，以及调节口腔微生物菌群的方法，为乳牙患龋的治疗提供更加科学和有效的方案。

Abstract:

Objective To investigate the relationship between the oral microflora and the effect of transitional restoration in children with deciduous teeth caries.Methods A total of 108 children with deciduous teeth who were treated in Zhumadian Central Hospital from March 2021 to January 2023 were selected as the study objects. According to the degree of deciduous teeth caries, the study subjects were divided into the mild caries group (58 cases) and the severe caries group (50 cases), so as to explore the influence of different degrees of caries on the relationship between oral microflora and transitional restoration effect. Basic information of the patients was collected, including gender, age, orthodontic treatment history, bleeding after brushing, tooth loosening, weak chewing, periodontal treatment history, and family history of periodontitis. Oral bacterial strains were determined, and the relationship between the oral microflora and the effect of transitional restoration in children with deciduous teeth was analyzed.Results The proportion of beneficial bacteria such as Streptococcus salivarius, Lactobacillus rhamnosus, Lactobacillus plantarum, Lactobacillus reuteri, Lactobacillus helveticus, Lactobacillus brevis, Lactobacillus lactis, Bifidobacterium, and Lactobacillus paracasei in the mild caries group was higher than that in the severe caries group (P<0.05). The proportion of harmful bacteria such as Streptococcus mutans, Streptococcus sobrinus, Actinomyces, and Lactobacillus acidophilus in the mild caries group was lower than that in the severe caries group (P<0.05). The proportion of harmful bacteria after repair was lower than before repair, while the proportion of beneficial bacteria was higher than before repair (P<0.05). Streptococcus mutans, Streptococcus sobrinus, Actinobacter baumannii, Lactobacillus acidophilus, Streptococcus salivarius, Lactobacillus rhamnosus, Lactobacillus plantarum, Lactobacillus rossiae, Lactobacillus helveticus, Lactobacillus brevis, Lactobacillus lactis, Bifidobacterium bifidum, Lactobacillus paracaseus, and other bacterial strains are factors affecting the oral health of children with dental caries (P<0.05).Conclusion There is a certain correlation between the oral microflora and the effect of transitional restoration in children with deciduous teeth caries, which provides a scientific basis for optimizing the treatment of deciduous teeth caries. Future studies may further explore the influence of different treatment methods on the relationship between oral microflora and transitional restoration efficacy in children with decidary teeth, and the methods to regulate oral microflora, so as to provide a more scientific and effective plan for the treatment of deciduous teeth caries.