雾化吸入布地奈德联合酚妥拉明治疗患儿感染性肺炎的应用效果

Effect of aerosol inhalation of budesonide combined with phentolamine on children with infectious pneumonia

摘要:

目的 探究雾化吸入布地奈德联合酚妥拉明治疗患儿感染性肺炎的应用效果。方法 选取2019年7月至2022年9月河南科技大学第二附属医院收治的感染性肺炎患儿82例作为研究对象。按随机数字表法分为观察组（41例）和对照组（41例），对照组给予雾化吸入布地奈德治疗，观察组给予雾化吸入布地奈德联合酚妥拉明治疗。比较两组患者的临床疗效，治疗前后的炎症因子［降钙素原（PCT）、C反应蛋白（CRP）、白细胞介素-6（IL-6）］以及不良反应的发生情况。结果 观察组的临床疗效（39例/41例，95.12%）明显高于对照组（32例/41例，78.05%）（P<0.05）。治疗后观察组和对照组的PCT、CRP、IL-6水平均下降，且观察组的PCT、CRP、IL-6水平均低于对照组（P<0.05）。观察组和对照组的不良反应总发生率分别为4.88%（2例/41例）、9.76%（4例/41例），差异无统计学意义（P>0.05）。结论 感染性肺炎患儿在应用雾化吸入布地奈德联合酚妥拉明治疗后，患儿的临床疗效明显提高，其机体炎症反应得到改善，临床应用价值较高。

Abstract:

Objective To explore the effect of aerosol inhalation of budesonide combined with phentolamine in the treatment of children with infectious pneumonia.Methods Eighty-two children with infectious pneumonia admitted to Second Affiliated Hospital of Henan University of Science and Technology from July 2019 to September 2022 were selected as the research objects. According to the random number table, they were divided into the test group (41 cases) and the matched group (41 cases). The matched group was treated with atomized budesonide, and the test group was treated with atomized budesonide combined with phentolamine. The clinical effects of the two groups were compared, the levels of inflammatory factors [procalcitonin (PCT), C-reactive protein (CRP), interleukin 6 (IL-6)] before and after treatment, as well as the occurrence of adverse reactions.Results The clinical efficacy of the test group (39 cases/41 cases, 95.12%) was significantly higher than that of the matched group (32 cases/41 cases, 78.05%) (P<0.05). After treatment, the PCT, CRP, and IL-6 levels in the test group and matched group decreased on average, and the PCT, CRP, and IL-6 levels in the test group were lower on average than those in the matched group (P<0.05). The total incidence of adverse reactions in the test group and matched group was 4.88% (2 cases/41 cases) and 9.76% (4 cases/41 cases), respectively, without a difference that is obviously significant (P>0.05).Conclusion After the treatment of aerosol inhalation of budesonide combined with phentolamine in children with infectious pneumonia, the clinical efficacy of children with infectious pneumonia has significantly improved, and their inflammatory reaction have been improved, with high clinical application value.