羟考酮在心肌缺血再灌注损伤中的作用

Role of oxycodone in myocardial ischemia-reperfusion injury

摘要:

缺血性心脏病是全球最重要的死亡原因之一，而心肌缺血再灌注损伤（MIRI）是缺血性心脏病常见的并发症。目前，临床上尚无针对MIRI的有效防治方法。在过去几十年里，羟考酮不仅作为镇痛药得到广泛应用，并且由很多研究发现其对于保护心肌组织的MIRI有一定作用。该综述主要围绕羟考酮能够通过抑制氧化应激，抑制炎性因子表达，保护心肌内皮细胞完整性等对MIRI 起到治疗与预防作用。旨在回顾已发表的关于羟考酮在MIRI中的相关作用机制，并为该领域的进一步研究提供参考。

Abstract:

Ischemic heart disease is one of the most important causes of death in the world, and myocardial ischemia reperfusion injury (MIRI) is a common complication of ischemic heart disease. Currently, there is no effective treatment for MIRI. Over the past few decades, oxycodone has not only been widely used as an analgesic, but also has been found by many studies to have a certain effect on the protection of MIRI of myocardial tissue. This review mainly focuses on the therapeutic and preventive effects of oxycodone on MIRI by inhibiting oxidative stress, inhibiting the expression of inflammatory factors, and protecting the integrity of myocardial endothelial cells. The purpose of this paper is to review the published mechanisms of oxycodone in MIRI and provide references for further research in this field.