孕期血清同型半胱氨酸、早期维生素D水平与外周血联合检测在妊娠期糖尿病筛查中的应用价值

Application value of prenatal Hcy, early vitamin D level and peripheral blood combined detection in the screening of gestational diabetes mellitus

摘要:

目的 探讨孕期血清同型半胱氨酸（Hcy）、早期维生素D水平与外周血联合检测在妊娠期糖尿病的筛查的中应用价值。方法 选取2020年2月至2022年5月于洛阳市妇幼保健院接受检查的82例孕妇作为研究对象，采用随机数字表法，依据是否发生妊娠期糖尿病将其分为两组，将伴有妊娠期糖尿病的孕妇归为研究组（41例），未伴有妊娠期糖尿病的孕妇归为对照组（41例）。比较两组研究对象的孕期血清Hcy、早期维生素D水平与外周血指标，评估联合检测对妊娠期糖尿病患者的临床预测价值。结果 研究组血清Hcy水平高于对照组，维生素D水平低于对照组（P<0.05）。研究组糖化血红蛋白（HbA1c）和血小板与淋巴细胞的比值（PLR）水平高于对照组（P<0.05）。建立受试者工作特征（ROC）曲线，结果显示孕期血清Hcy、早期维生素D水平、外周血指标（HbA1c、PLR）单独检测及联合检测的曲线下面积分别为0.984、0.921、0.909、0.658、0.996，可见联合检测对妊娠期糖尿病具有良好的预测诊断价值。结论 孕期血清Hcy、早期维生素D水平与外周血联合检测对妊娠期糖尿病具有良好的诊断价值，对敏感指标进行检测，为妊娠期糖尿病的临床诊断提供客观的指标支持，对孕期保健管理具有重要意义。

Abstract:

Objective To investigate the application value of combined detection of Hcy, early vitamin D and peripheral blood in the screening of gestational diabetes mellitus.Methods A total of 82 pregnant women who were examined in Luoyang Maternal and Child Health Hospital from February 2020 to May 2022 were selected as the study objects. A random number table method was used to divide them into two groups according to whether they had gestational diabetes. Pregnant women with gestational diabetes were classified as the study group (41 cases), and those without gestational diabetes were classified as the control group (41 cases). The prenatal Hcy, early vitamin D levels and peripheral blood indicators of the two groups were compared to evaluate the clinical predictive value of combined detection in gestational diabetes patients.Results The Hcy index level of the study group was significantly higher than that of the control group, and the vitamin D index was lower than that of the control group (P<0.05). The levels of HbA1c and PLR indexes in the study group were significantly higher than those in the control group (P<0.05). ROC curve was established, and the curve results showed that the area under the curve of single detection of Hcy during pregnancy, early vitamin D level, peripheral blood indicators (HbA1c, PLR) and the combined detection was 0.984 0.921, 0.909, 0.658, and 0.996, respectively, indicating that the combined detection had a good value in predicting and diagnosing gestational diabetes mellitus.Conclusion The combined detection of Hcy, early vitamin D and peripheral blood in pregnancy has good diagnostic value for gestational diabetes mellitus. Detection of sensitive indicators provides objective indicator support for clinical diagnosis of gestational diabetes mellitus, which is of great significance for health care management during pregnancy.