Abstract:Objective To study the effect of the detection of tumor marker carcinoembryonic antigen (CEA), inflammatory factors procalcitonin (PCT) and high-sensitivity C-reactive protein (hs-CRP) in the diagnosis of lung cancer.Methods Totally 200 patients with suspected lung cancer admitted to Pingdingshan Hospital of Traditional Chinese Medicine from January 2020 to December 2022 and 100 healthy volunteers who underwent physical examination in our hospital at the same time were taken as research objects. Blood samples were collected from all patients to detect the levels of tumor markers and inflammatory factors.Results The pathological examination results of 200 suspected lung cancer patients showed that there were 100 lung cancer patients and 100 patients with benign lung lesions. There were significant differences in CEA levels, PCT and hs-CRP levels among lung cancer patients, benign lung disease patients, healthy volunteers, and non-small cell lung cancer and small cell lung cancer patients (P<0.05). Among 100 lung cancer patients, the positive detection rates of CEA, PCT, and hs-CRP were 69.00%, 61.00%, and 54.00%, respectively. Among 100 patients with benign lung lesions, the positive detection rates of CEA, PCT, and hs-CRP were 9.00%, 47.00%, and 40.00%, respectively. Among 100 healthy volunteers, the positive detection rates of CEA, PCT, and hs-CRP were 3.00%, 0.00%, and 1.00%, respectively. The positive detection rates of CEA, PCT, and hs CRP among the three groups were statistically significant (P<0.05). Using pathological examination as the gold standard, the diagnostic sensitivity, specificity, and accuracy of inflammatory factors combined with tumor markers are 85.00%, 96.00%, and 92.33%.Conclusion CEA combined with PCT and hs-CRP detection has high sensitivity, specificity, and accuracy in the diagnosis of lung cancer.