CPEB4的表达与肿瘤临床病理特征和预后关系的生物信息学分析

Bioinformatics analysis of the relationship between CPEB4 expression and clinical pathological characteristics and prognosis of tumors

摘要:

目的 探讨CPEB4基因在肿瘤中是否为一种肿瘤标志物并评估CPEB4在泛癌中的预后状况、临床相关性分析及肿瘤微环境之间的关系。方法 在线检索PubMed、中国知网、维普和万方数据库中存在CPEB4关于人体肿瘤表达的相关文献，纳入并汇总相关肿瘤细胞中表达情况的研究，对符合标准的文献提取出相应的临床数据并进行Meta分析。提取癌症基因组图谱（TCGA）数据库中的样本信息进行泛癌分析并拓展CPEB4高低表达组对不同肿瘤患者的临床相关性研究、预后程度与免疫之间的关系。结果 荟萃分析结果显示CPEB4为晚期肾透明细胞癌、非小细胞肺癌、神经胶质瘤、结直肠腺癌、胃腺癌患者的不良预后因子；对泛癌差异分析结果统计，CPEB4在肿瘤中为两极化因子，针对泛癌中CPEB4表达与肿瘤突变负荷（TMB）、微卫星不稳定性（MSI）、免疫细胞相关性与其他免疫相关基因之间的关系并进行GSEA通路富集分析，验证并拓展荟萃分析的结果。结论 CPEB4作为泛癌中的矛盾因子，可作为肿瘤患者病情的检测指标及预后的重要参考因素。

Abstract:

Objective To investigate whether CPEB4 gene is a tumor marker in tumors and to evaluate the relationship between prognosis, clinical correlation analysis and tumor microenvironment of CPEB4 in pan-carcinoma.Methods Online search of CPEB4 related literature on human tumor expression in PubMed, CNKI, Weipu and Wanfang databases, include and summarize the expression in related tumor cells, extract corresponding clinical data from the literature that meets the standards and conduct meta-analysis. Extract the sample information in the TCGA (Cancer Genome Atlas) database for pan-carcinogenic analysis and expand the relationship between clinical correlation research, prognosis degree and immunity of CPEB4 high and low expression groups in different tumor patients.Results The results of meta-analysis showed that CPEB4 was a poor prognostic factor in patients with advanced renal clear cell carcinoma, non-small cell lung cancer, glioma, colorectal adenocarcinoma and gastric adenocarcinoma. The results of pan-cancer differential analysis showed that CPEB4 was a polarizing factor in tumors, and the relationship between CPEB4 expression and tumor mutation burden (TMB), microsatellite instability (MSI), immune cell correlation and other immune-related genes in pan-carcinoma, and GSEA pathway enrichment analysis were carried out, and the results of meta-analysis were verified and expanded.Conclusion As a paradoxical factor in pan-carcinoma, CPEB4 can be an important reference factor for the detection index and prognosis of some tumor patients.