脊髓电刺激对实验房颤犬左侧星状神经节的影响

Effect of spinal electrical stimulation on left stellate ganglion in experimental dogs with atrial fibrillation

摘要:

目的 探讨低强度脊髓电刺激（SCS）对实验房颤犬左侧星状神经节（LSG）功能的影响。方法 20只健康成年比格犬在左心耳处行快速心房起搏（RAP）以诱导急性重构，建立房颤模型，随机分为两组：实验组10只，以引起肌肉震颤的最低电压强度为刺激阈值对T1-2节段脊髓神经予以高频电刺激，使用90%的阈值强度进行SCS并持续6 h；对照组10只在T1-2附近体表皮肤同样予以低强度刺激6 h。分别在基础状态、6 h末测定递增电压刺激LSG引起的心率变化。横坐标和纵坐标分别以电压刺激强度与最大心率（HR）变化（HR降低的最大百分比）绘出LSG的心率-电压反应曲线。结果 对照组LSG的心率-电压反应曲线没有明显变化；实验组LSG的心率-电压反应曲线逐渐迟钝，而且相同电压引起的心率降低的百分比明显逐渐降低。结论 低强度脊髓电刺激可以抑制实验房颤犬LSG的功能。

Abstract:

Objective To investigate the effect of low-intensity spinal electrical stimulation (SCS) on the left stellate ganglion (LSG) function in experimental dogs with atrial fibrillation.Methods Twenty healthy adult beagle dogs underwent rapid atrial pacing (RAP) at the left atrial appendage to induce acute remodeling and establish an atrial fibrillation model, then they were randomly divided into two groups. Ten dogs in the experimental group were subjected to high-frequency electrical stimulation of the T1-2 spinal cord nerve using the minimum voltage intensity that caused muscle tremors as the stimulation threshold, and SCS was performed at 90% threshold intensity for 6 hours. Ten dogs in the control group were also subjected to low-intensity stimulation on the surface skin near T1-2 for 6 hours. Heart rate changes induced by increasing voltage stimulation with LSG were determined in the basal state and at the end of 6 hours. The heart rate-voltage response curve for LSG was plotted against the percentage of stimulation voltage change in heart rate as abscissa and ordinate, respectively.Results The heart rate-voltage response curve of the control LSG did not change significantly; the heart rate-voltage response curve of the experimental LSG gradually became sluggish, and the percentage of the heart rate reduction caused by the same voltage decreased.Conclusion Low-intensity spinal electrical stimulation can inhibit the function of LSG in experimental dogs with atrial fibrillation.