妊娠晚期糖尿病孕妇血清25-羟基维生素D水平及影响因素分析

Serum 25 hydroxyvitamin D level and its influencing factors in pregnant women with late gestational diabetes mellitus

摘要:

目的探讨妊娠晚期糖尿病孕妇血清25-羟基维生素D水平,对其影响因素进行分析。方法收集2019年1月至2020年6月来佛山市顺德区伦教医院进行产前检测并确诊的70例妊娠晚期糖尿病孕妇作为观察组,选取同时期进行产检的正常孕妇70例作为对照组。对两组孕妇血清25-羟基维生素D水平进行检测,并分析其可能影响因素。结果观察组与对照组孕妇的血清25-羟基维生素D水平比较明显偏低(P<0.05),观察组孕妇变化更为显著(P<0.05)。经过单因素研究分析孕妇年龄、孕妇体重增加、孕妇基础体重指数、餐后1 h血糖以及空腹血糖是孕妇血清25-羟基维生素D水平偏低的危险因素(P<0.05),相关性分析显示年龄、孕前体重指数、体重增加、空腹血糖以及餐后1 h血糖与孕妇血清25-羟基维生素D水平具有相关性。结论妊娠晚期糖尿病孕妇血清25-羟基维生素D水平偏低,因此,加强对妊娠晚期糖尿病孕妇25-羟基维生素D的监控对其能够及时、以及足量地补充维生素D提供依据。

Abstract:

【Objective】To investigate the serum 25 hydroxyvitamin D level of pregnant women with late gestational diabetes mellitus and analyze its influencing factors.【Methods】From January 2019 to June 2020,70 cases of pregnant women with gestational diabetes mellitus diagnosed by prenatal examination in our hospital were selected as the observation group,and 70 cases of normal pregnant women with prenatal examination at the same time were selected as the control group.The serum 25 hydroxyvitamin D levels of two groups of pregnant women were detected,and the possible influencing factors were analyzed.【Results】The serum 25-hydroxyvitamin D levels of pregnant women in the observation group were significantly lower than those in the control group(P<0.05),while the changes in the observation group were more significant(P<0.05).A single factor study showed that the age of pregnant women,the weight gain of the pregnant women,the basic body mass index of the pregnant women,1 hour postprandial blood glucose,and the fasting blood glucose were the risk factors of low serum 25-hydroxyvitamin D levels in pregnant women(P<0.05),and correlation analysis showed that age,pre-pregnancy BMI,weight gain,fasting blood glucose and 1 hour postprandial blood glucose were correlated with the serum 25-hydroxyvitamin D level of pregnant women.【Conclusion】The serum 25-hydroxyvitamin D level of pregnant women with diabetes in the third trimester of pregnancy is low.Therefore,we should strengthen the monitoring of 25-hydroxyvitamin D in pregnant women with diabetes in the third trimester of pregnancy to provide a basis for timely and sufficient vitamin D supplementation.