奥利司他胶囊联合胰岛素强化治疗初诊肥胖2型糖尿病患者的疗效分析

Effect of orlistat capsule combined with intensive insulin therapy on newly diagnosed obese type 2 diabetes mellitus

摘要:

目的观察奥利司他胶囊联合胰岛素强化治疗初诊肥胖2型糖尿病(T2DM)的治疗效果。方法选取2019年2月至2020年2月新乡市中心医院收治的86例初诊肥胖T2DM患者,采用随机数字表法分为联合组与对照组,每组43例。对照组予以胰岛素强化治疗,联合组在对照组基础上予以奥利司他联合治疗。比较两组患者治疗前与治疗3个月后一般体格检查[体重、体重指数(BMI)、体脂量(PBF)]、糖代谢指标[糖化血红蛋白(HbAlc)、空腹血糖(FPG)、餐后2 h血糖(2 hPG)]及脂代谢指标[血清甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)]水平变化情况,记录并及时处理两组患者治疗过程中药物不良反应的发生情况。结果两组治疗3个月后体重、BMI、PBF、HbAlc、FPG、2 hPG、TC、TG、LDL-C水平较治疗前降低,且联合组低于同一时间对照组(P<0.05);而两组治疗3个月后HDL-C水平较治疗前升高,且联合组高于同一时间对照组(P<0.05)。两组患者治疗过程中药物不良反应发生率比较,差异无统计学意义(P>0.05)。结论奥利司他胶囊联合胰岛素强化治疗初诊肥胖T2DM患者效果更佳,安全性良好,有较高的临床推广应用价值。

Abstract:

【Objective】To observe the effect of orlistat capsule combined with intensive insulin in the treatment of newly diagnosed obese type 2 diabetes mellitus(T2DM).【Methods】Eighty-six cases of newly diagnosed obese T2DM treated in our hospital from February 2019 to February 2020 were randomly divided into combined group and control group,43 cases in each group.The control group was given intensive insulin therapy,and the combined group was given orlistat combined therapy on the basis of the control group.The general physical examination[body weight,body mass index(BMI),percent body fat(PBF)],glucose metabolism indexes[glycosylated hemoglobin(HbAlc),fasting blood glucose(FPG),postprandial blood glucose(2hPG)]and lipid metabolism indexes[serum triglyceride(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C)and highdensity lipoprotein cholesterol(HDL-C)]were compared between the two groups before treatment and after 3 months of treatment.The occurrence of adverse drug reactions in the treatment process of the two groups was recorded and timely dealt with.【Results】After 3 months of treatment,the body weight,BMI,PBF,HbAlc,FPG,2hPG,TC,TG,LDL-C levels of the two groups were significantly decreased,which was significantly lower in the combined group than in the control group at the same time(P<0.05);the HDL-C levels of the two groups were significantly increased,which was significantly higher in the combined group than in the control group at the same time(P<0.05).There was no significant difference in adverse drug reactions between the two groups(P>0.05).【Conclusion】Orlistat capsule combined with insulin intensive treatment of newly diagnosed obese T2DM has better effect,good safety and high clinical application value.