肝硬化患者血清MMP-2和TIMP-1的测定及临床意义

Detection of serum MMP-2 and TIMP-1 in liver cirrhosis

摘要:

目的观察肝硬化患者血清基质金属蛋白酶-2(MMP-2)及其抑制因子基质金属蛋白酶抑制因子-1(TIMP-1)的含量变化,探讨其在肝硬化发生发展过程中的作用和意义.方法用ELISA法检测30例慢性乙型病毒性活动性肝炎、30例肝硬化患者以及32例健康体检者血清MMp-2和TIMP-1的含量.结果与正常对照组相比,肝硬化组血清MM P-2水平升高,(P＜0.05);而慢性活动性肝炎血中MMP-2值与对照组无差别.慢性活动性肝炎组、肝硬化组血清TIMP-1水平显著高于对照组(P＜0.05).结论血清MMP-2水平可检测肝硬化,在慢性活动性肝炎病人若MMP-2水平升高则可表明已发展为肝硬化;血清TIMp-1水平可反映病人的慢性肝脏炎症及纤维化.

Abstract:

Objective: To investigate the role and clinical significance of serum MMP-3 and TIMP-1 in chronic hepatitis B and liver cirrhosis. Methods: Serum MMP-2, TIMP-1 levels were measured by ELISA in 30 patients with chronic hepatitis B and 30 patients with liver cirrhosis and 32 healthy persons. Results: The level of MMP-2, and TIMP-1 in patients with chronic hepatitis B and liver cirrhosis were higher than those of control (P<0.05). The level of MMP-2, and TIMP-1 in patients with liver cirrhosis were higher than those of patients with chronic hepatitis (P<0.05). Conclusion: Serum levels of MMP-2 may be able to detect liver cirrhosis. Serum levels of TIMP -1 may be an indicator of chronic hepatitis and cirrhosis.