蛋白芯片法检测CA242,CA19-9和CEA对胰腺癌诊断价值

Diagnostic value of CA242,CA19-9 and CEA by application of protein chip diagnosis system in pancreatic carcinoma

摘要:

目的探讨用蛋白芯片法检测CA242,CA19-9和CEA对胰腺癌的诊断价值.方法用蛋白芯片法测定40例胰腺癌、55例非胰腺肿瘤、11例慢性胰腺炎、17例良性疾病患者和22例健康人群血清CA242,CA19-9和CEA含量.结果CA242,CA19-9和CEA对胰腺癌有诊断价值,其中CA242敏感性、特异性、阳性预测值、阴性预测值较好,分别为75.0%,83.8%,63.8%和89.8%,联合检测可提高检测的特异性和阳性预测值;而且CA19-9与胰腺癌分期正相关.结论蛋白芯片法检测CA242,CA19-9和CEA结果可靠,对胰腺癌的诊断有一定的价值.

Abstract:

Objective: To investigate the diagnostic value of CA242, CA19-9 and CEA by application of protein chip diagnosis system in the Pancreatic carcinoma. Methods: The protein chip was used to determine and analyze the concent of CA242, CA19-9 and CEA in 40 patients with pancreatic carcinoma, 55 patients with non-pancreas tumors, 11 patients with chronic pancreatitis, 17 patients with benign disease and 22 healthy person. Results: CA242, CA19-9 and CEA were significant statistical, among which CA242 was the best marker with sensitivity of 75.0%, specificity of 83.8%, positive predictive value of 63.8% and negative predictive value of 89.8%. The specificity and positive predictive value of the combined assay were elevated. The content of CA19-9 correlated with the stage of pancreatic carcinoma. Conclusion: The value of CA242, CA19-9 and CEA by application of protein chip diagnosis system is reliable, with ideal diagnostic value.