含60%氦的氦氧混合气体对改善呼吸道疾病缺氧症状的效果探讨

Effect of helium-oxygen mixture (He-O2) containing 60% helium on improvement of anoxia syndrome in respiratory diseases

摘要:

目的探讨含60%氦的氦氧混合气体对改善呼吸道疾病缺氧症状的效果.方法测定非吸烟健康志愿者呼吸氯氧混合气体前后肺活量及其组成补呼气容积和深吸气量并比较它们的变化.结果呼吸含60%氦的氦氧混合气体后,肺活量、补呼气容积呈大幅增加,深吸气量呈轻微下降变化,其中补呼气容积前后变化具有显著差异(P＜0.05).结论呼吸含60%氦的氦氧混合气体后,肺活量及其组成补呼气容积和深吸气量的变化趋势与呼吸含80%氯的氦氧混合气体相一致,且变化率相近似,可获得与含80%氦的氦氧混合气体相仿的临床治疗效果.

Abstract:

Objective: To investigate the effect of helium-oxygen mixture (He-O2) containing 60% helium on improvement of anoxia syndrome in respiratory diseases. Methods: Vital capacity (VC) and its component expiratory capacity (ERV) and inspiratory capacity (IC) were detected in non-smoking healthy volunteers before and after breathing helium-oxygen mixture and the changes were compared. Results: After breathing He-O2 containing 60% helium, VC and ERV increased enormously, while IC decreased mildly, among which the change of ERV showed significant difference (P<0.05). Conclusions: The changing tendencies of vital capacity and its components ERV and IC after breathing He-O2 containing 60% helium are consistent with those after breathing He-O2 containing 80% helium, and their changing rates are also similar, which indicate that He-O2 containing 60% helium may has the same therapeutic effect as that containing 80% helium does in clinic.