Objective: To study the correlation between Recurrent Oral Ulcer and depression and anxiety. Methods: A case-control study was adopted. All patients in control-group were required to fill in the "Self-rating Depression Scale(SDS)" and "Self-rating Anxiety Scale(SAS)", then the standard scores and difference between two groups were analysed. Results: There is a statistical difference(P <0.05) between two groups in standard scores. Conclusion: There is significant correlation between Recurrent Oral Ulcer and depression and anxiety.