急性淋巴细胞白血病免疫表型与临床特征分析

Analysis of immunophenotypic characterization and clinical features in acute lymphatic leukemia

摘要:

目的探讨急性淋巴细胞白血病不同免疫表型的临床特点.方法使用8种抗CD单抗测定90例成人急性淋巴细胞白血病免疫表型,在此基础上对纯T,B系表型的病例进行临床特征分析.结果急性淋巴细胞免疫分型与FAB形态学分型基本符合,T系白细胞总数明显高于B系,在淋巴结肿大、肝脾肿大等体征上两者无显著性差异,两型的预后特点有待进一步观察.结论急性淋巴细胞白血病的免疫分型对其诊断和治疗有指导意义.

Abstract:

Objective: To explore the immunophenotypic characterization and clinic features of acute lymphatic leukemia. Methods: The immunophenotyping in 90 adult patients with acute lymphoblastic leukemia (ALL) was determined by using indirect immunofluoresent method. Eight monoclonal CD antibodies consisting of anti-CD2,-CD7,-CD10,-CD19,-CD13,-CD14,-CD33 and anti-HLA-DR monoclonal antibodies were applied conventionally. The clinical features including white blood cell (WBC), the rates of hepatomegaty, splenomegaty and nodule enlargement were also observed. Results: Immunophenotyping had high corresponding rate to FAB morphological typing in diagnosing ALL, and WBC was higher in patients with pure T-lineage type ALL than in pure B-lineage type ALL, while other clinical features had no significant difference in these two types ALL. It seemed that the effect of chemotherapy in pure B-lineage ALL was better than in pure T-lineage ALL. Conclusion: Immunoghenotypic characterization is a great help in the diagnosis and treatment of ALL.