马法兰隔离肝灌注治疗不可切除晚期肝癌

Isolated liver perfusion with melphalan for unresectable malignant liver tumors

摘要:

目的了解马法兰隔离肝灌注治疗不可切除晚期肝癌的疗效.方法2003年3月,在治疗不可切除性原发性肝癌中采用了高温下马法兰隔离肝灌注治疗.结果术后第6天,肿瘤组织出现了明显的液化、坏死.结论马法兰隔离肝灌注治疗是治疗不可切除性原发性肝癌的新技术.熟练的外科医生,不仅要了解马法兰隔离肝灌注治疗手术前的并发症,更要在术前术后对病人进行仔细监测,以避免急性凝血功能损害以及肝肾功能衰竭.

Abstract:

Objective:To understand the efficiency of iso lated liver perfusion with melphalan for unresectable malignant liver tumors. Methods:In March 2003, we adopted Isolated Liver Perfusion (ILP) with melphalan under high temperature in the treatment of an unresectable primary liver tumor.Results: On the sixth postoperative day, obvious liquefaction necrosis occurred in the tu mor. ILP is a new and effective technique for treating unresectable primary tumors, particularly metastatic tumors. Conclusions:While performing the surgery, a skillful doctor should not only be aware of possible preoperative complications of ILP , but also monitor patients very carefully during both the perioperative and postoperative periods in order to avoid acute impaired coagulation function and liver-kidney function failure. In this paper, the ILP conditions, trends and recommendations for further study are discussed.