肝胆肿瘤及肝胆道感染患者外周血、胆汁中内皮素、降钙素及基因相关肽浓度变化的意义

Significance of concentrations of endothelin and calcitonin gene-related peptide in peripheral blood and bile in patients with hepatobiliary carcinoma and hepatobiliary duct infection

摘要:

目的探讨胆道感染及肝胆肿瘤患者外周血、胆汁中内皮素(ET)及降钙素基因相关肽(CGRP)浓度变化的意义.方法采用放射免疫分析检测120例肝胆道感染和肝胆肿瘤患者外周血、胆汁中ET、CGRP的浓度.结果肝胆感染患者外周血中ET、CGRP的质量浓度分别为(56.85±16.54)pg/ml和(96.34±20.05)pg/ml;肝胆肿瘤组的ET、CGRP的值分别为(107.35±14.44)pg/ml和(36.37±14.79)pg/ml,与对照组ET及CGRP的值(42.88±11.96)pg/ml、(24.04±17.45)pg/ml比较差异有显著性(P＜0.01),肝胆道感染及肿瘤患者胆汁中ET值为(61.36±13.72)pg/ml、(71.38±16.27)pg/ml,CGRP值为(250.07±43.19)pg/ml、(198.71±35.68)pg/ml,与对照组的ET、CGRP值[(18.56±7.40)pg/ml,(165.36±28.07)pg/ml]比较差异有显著性(P＜0.01).结论ET、CGRP参与了肝胆感染及肝胆肿瘤疾病发病过程,其作用机制尚需深入研究.

Abstract:

Objective: To study the significance of concentration of endothelin (ET) and calcitionin gene - related peptide(CGRP) in peripheral blood and bile in patients with hepatobiliary carcinoma and hepatobiliary duct infection. Methods:The concentration of endothelin and calcitionin gene related- protein were detected by radioimmunoassay in 120 cases of bepatobiliary carcinoma and hepatobiliary duct infection. Results:The concentrations of ET and CGRP in peripheral blood and bile in patients with hepatobiliary carcinoma and hepatobiliary duct infection are( 107.35 ± 14.44) pg/ml, ( 36.37 + 14.79 ) pg/ml, ( 56.85 + 16.54) pg/ml and (96.34 + 20. 025 ) pg/ml,(250.07 + 43.19 ) pg/ml ( 198.71 ± 35.68 ) pg/ml, respectively. Compared with control ( 42.88 ± 11.96 ) pg/ml,(24.04 ± 17.45)pg/ml and (18.56 ± 17.40)pg/ml, (165.36 ±28.07)pg/ml, the difference was significant (P＜0.05,0.01 ). Conclusion:The ET and CGRP in peripheral blood and bile have effect on hepatobiliary carcinoma and hepatobiliary duct infection. But the pathogenesis should be further studied.