<正> Objective: To investigate the effect of prostaglandin E1 (PGE1) (Alprostadii injection) on patientswith primary nephrotic syndrome(PNS). Methods: 37 patients with PNS were recruited to study the effect ofprostaglandin E1 on platelet aggregation function [PAG(5,) PAG(m)], serum total protein(TP), albumin(Al),blood urea nitrogen(BUN), serum creatinine(Scr), cholesterol(CHO), triglyceride(TG), protein in 24-hour urine(Pr/24h) and platelet account (PLT). Results: TP, Al, CHO, TG, BUN, Scr, Pr/24h, PAG(5) and PAG(m) inPNS group before treatment were significantly different from those in control group(P<0.05, P<0.01) while no