<正> Objective:To compare the targeting effects of lactosaminated alginate(AlgNP), polyethylene glycol-coated hydroxyapatite-poly-L-lysine nanoparticles (PLL-PCHNP)and relative nonlactosaminated ones load-ed with exogenous gene on liver via peripheral intravenous route. Methods: Preparation of AlgNP based on control ofgelification phenomenon of algiante by calcium ions and HA-PLLNP with collosol-gel method, both further modi-fied with lactosaminated-poly-L-lysine synthesized by reductive lactosamination. We used pEGFP_(Cl) as the re-
Abstract:
<正> Objective:To compare the targeting effects of lactosaminated alginate(AlgNP), polyethylene glycol-coated hydroxyapatite-poly-L-lysine nanoparticles (PLL-PCHNP)and relative nonlactosaminated ones load-ed with exogenous gene on liver via peripheral intravenous route. Methods: Preparation of AlgNP based on control ofgelification phenomenon of algiante by calcium ions and HA-PLLNP with collosol-gel method, both further modi-fied with lactosaminated-poly-L-lysine synthesized by reductive lactosamination. We used pEGFP_(Cl) as the re-
